Pharmaceutical tablets may be defined as the solid unit dosage form of one or more medicaments with or without suitable excipients and prepared either by moulding or by compression. A tablet comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from the powder into a solid dose. The compressed tablet is the most popular dosage form in use today. About two-thirds of all drugs currently prescribed are in solid form in half and of these are as compressed tablets.
Major Categories of Tablets:
Uncoated – a single layer or more than one layer of formulation that consists of active ingredients and excipients compressed together without any additional coat or cover
Dispersible – tablets that have film coats or uncoated tablets that form a uniform dispersion when it is suspended in water
Effervescent – tablets that are uncoated and are intended to dissolve and disperse when mixed with organic acid or bicarbonate to produce gaseous carbon dioxide (CO2). The CO2 disintegrates the tablet to produces a suspension of powdered material that is readily absorbed
Modified release – coated or uncoated tablets that are designed to release the active ingredient when the desired activity or condition is reached. Examples: enteric coated, delay-release and prolonged release
Enteric coated – also called as gastro-resistant, these tablets are resistant to acidic gastric juices. They are coated with a polymer material such as Cellulose acetate phthalate, Cellulose acetate trimellitate, or acrylate polymers.
Prolonged release – also called as extended release or sustained release tablets. These tablets are formulated in such a way that the release of active ingredient is controlled over a prolonged period. Special excipients are needed to be able to produce prolonged release tablets.
Soluble – tablets that are dissolved in water before being administered. These may be coated or uncoated.
Tablets that are for mouth use – these tablets are formulated to release active ingredients when placed in the buccal cavity or mouth area. They are used when a patient has difficulty swallowing or when fast release into the bloodstream is required. Examples are buccal and sublingual tablets, lozenges and troches.
Buccal – tablets placed in between the gingival (gums) and cheek area
Sublingual – placed underneath the tongue
Implantable/Other Route – tablets that are placed in other areas of the body instead of the mouth (example, rectal or vaginal tablets).
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Advantages of tablets:
Ease and convenience of use
Fixed and metered dosages
Bitter tasting drugs can be masked with coated tablets
Unstable API can be administered through coated tablets
Modified release of active ingredients ensures patient’s compliance and increases therapeutic effect
Inexpensive form of dosage
Stability of API
Disadvantages:
Availability of drugs depends on several factors.
Onset of action of drugs is less compared with direct route such as IV.
Smaller and geriatric patients may find it harder to swallow tablets.
Solid dosage forms are forms or shapes where drug mixtures are placed, example of which include tablets and capsules. These solid dosage forms are administered orally.
Tablets are defined as Solid Pharmaceutical Dosage forms that contain drug substances. They may contain suitable diluents or are prepared through moulding or compression.
The concept of producing a tablet form dosage starts first at the company’s marketing department. With that said, the formulators are responsible in producing the said tablet. Below are some key points to consider when specifying the dies and press punches.
At LFA over the last 7 years we have seen a glimpse into every type of use for a tablet press. Nowadays when someone asks us how to press glass, or metal, or even coffee granules we are no longer surprised. One that was new to us was the pigeon problem.
Tablet Presses 
