Formulation Guide

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 116mg tablets with 6mm bisect tooling.

Note: If blend is not uniform, a premix of sodium flouride and sorbitol should be prepared separately before mixing with other excipients.

1. Pass all components through a 20 mesh sleeve.

2. Intensively mix sieved components.

3. Compress into 98.1mg tablets with 6mm tooling.

Note: If blend is not uniform, a premix of terazosin chloride and Ludipress� or lactose monohydrate should be prepared separately before mixing with other excipients.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 78mg tablets with 5mm bisect tooling.

Note: If blend is not uniform, a premix of active sodium flouride and Ludipress� or lactose monohydrate should be prepared separately before mixing with other excipients.

1. Mix all components.

2. Pass through a sieve.

3. Compress into 514mg tablets with 12mm bisect tooling.

1. Mix crospovidone, citric acid, and silicon dioxide.

2. Mix sucrose, saccharin sodium, and water.

3. Granulate crospovidone mixture with sucrose solution, then pass through a 20 mesh screen.

4. Mix magnesium stearate, sodium bicarbonate, and flavour mixture.

5. Mix magnesium stearate mixture with dry granulated mixture.

6. Compress into 1590mg tablets with 20mm bisect tooling.

1. Mix crospovidone with silicon dioxide.

2. Mix sucrose, saccharin sodium, flavours, and water.

3. Granulate crospovidone mixture with sucrose solution then sieve.

4. Dry the granulated mixture then add magnesium stearate.

5. Compress into 1280mg tablets with 20mm bisect tooling.

6. Note: Dosage of crospovidone may be increased to 2000mg by inrcreasing tablet weight to 2600mg.

Direct Compression

1. Mix all components.

2. Pass through a sieve.

3. Compress into 505mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 318mg tablets with 12mm bisect tooling.

Note: Due to the poor flowability of the powder the tabletting machine should be equipped with force feeder.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 254mg tablets with 8mm bisect tooling.

Note: Long term compatibility between aminophylline and lactose should be controlled.

1. Granulate mixture of items 1 and 2 with solution of items 4 and 5 (in a fluidized bed), sieve, add item 6, and press with high-compression force.

2. Compress into 620-mg tablets, using 12-mm biplanar punches.

Pass all components through a 0.8-mm sieve, mix, and press with medium-compression force.

1. Blend all ingredients in a twin-shell blender for 10 minutes.

2. Compress into 153 mg tablets.

1. Blend all ingredients, except stearic acid, for 20 minutes.

2. Screen in the stearic acid and blend for an additional 5 minutes.

Note: It is not possible to make chewable ascorbic acid tablets with over 50% active ingredient. Other directly compressible sugars such as EMDEX® could be used to replace Sucrose, DC. Magnesium stearate should be avoided in ascorbic acid formulations. Addition of a higher concentration of MCC will not usually increase tablet hardness.

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components.

4. Compress into 350mg tablets with 8mm bisect tooling.

1. Mix dimenhydrinate, lactose monohydrate, corn starch, and povidone.

2. Granulate dimenhydrinate mixture with isopropanol

3. Dry granulated mixture then pass through a 20 mesh sieve.

4. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

5. Mix crospovidone mixture with dry granulated mixture.

6. Compress into 210mg tablets with 9mm bisect convex tooling.

1. Mix lactose monohydrate and dicalcium phosphate.

2. Mix povidone and water.

3. Granulate lactose mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen.

5. Mix dried garlic powder and magnesium stearate.

6. Add garlic powder mixture to granulated mixture.

7. Compress into 312mg tablets with 9mm bisect convex tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 294mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 307mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 307mg tablets with 12mm bisect tooling.

1. Mix nitrofurantoin, 20g corn starch, and lactose.

2. Mix povidone and water.

3. Granulate nitrofurantoin mixture with povidone solution.

4. Dry granulated mixture then sieve.

5. Mix crospovidone, 8g corn starch, talc, and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 180mg tablets with 8mm bisect convex tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 339mg tablets with 10mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 346mg tablets with 12mm bisect tooling.

1. Mix phenytoin sodium, dicalcium phosphate, and sucrose.

2. Mix povidone and isopropanol+ethanol mixture.

3. Granulate phenytoin sodium mixture with povidone solution.

4. Dry granulated mixture then pass through 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 209mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 351mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through sieve.

3. Compress into 247mg tablets with 8mm bisect tooling.

1. Blend all ingredients, except magnesium stearate, for 25 minutes.

2. Screen in magnesium stearate and blend for an additional 5 minutes.

Note: Anhydrous lactose could be replaced with Fast Flo® lactose with no loss in tablet quality. This would reduce the need for a glidant.

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 152mg tablets with 8mm bisect tooling.

1. Mix all components, pass through a sieve, and press with high-compression force.

2. The 20-mm biplanar tablet has an average weight of 2.6 g.

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

Mix items 1-8 in a V-blender and mix for 15 minutes. Compress at low forces.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 289mg tablets with 9mm bisect convex tooling.

1. Mix starch and loratadine to form a uniform mixture

2. Mix remaining excipients (mannitol, aspartame, microcrystalline cellulose, colloidal silicon dioxide, purified talc, magnesium stearate, PVPK-30, sodium starch glycolate) step wise to the uniform mixture of powder.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 100mg tablets with 6mm bisect tooling.

1. Mix nifedipine and povidone.

2. Dissolve nifedipine mixture in methylene chloride.

3. Mix microcrystalline cellulose, corn starch, and crospovidone.

4. Granulate microcrystalline cellulose with nifedipine/methylene chloride solution.

5. Sieve then dry the granulated mixture.

6. Add magnesium stearate.

7. Compress into 223mg tablets with 8mm bisect convex tooling.

1. Mix all components.

2. Pass through a sieve.

3. Compress into 223mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 238mg tablets with 8mm bisect tooling.

1. Dry the Sodium Bicarbonate for 1 hour at 100.C, mix with the other components, pass all through a 0.8-mm sieve, compress.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 374mg tablets with 12mm bisect tooling.

1. Mix fucidine and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate fucidine mixture with povidone solution.

4. Dry then pass through a 20 mesh screen.

5. Mix crospovidone, silicon dioxide, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 200mg tablets with 9mm bisect convex tooling.

Note: To accelerate the disintegration rate, the amount of povidone should be reduced and add crospovidone whould be added in intra- extrgranular form.

1. Mix amoxicillin and corn starch.

2. Mix povidone and water.

3. Wet granulate amoxicillin mixture with povidone solution.

4. Dry the granulated mixture then pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 297mg tablets with 12mm bisect tooling.

1. Pass all components through a 35 mesh sieve.

2. Mix sieved components.

3. Compress into 267mg tablets with 12mm bisect tooling.

Note: To improve flowability of mixture, increase the amount of silicon dioxide or Ludipress�.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 278mg tablets with 8mm bisect tooling.

Mix all components, pass through an 0.8-mm sieve, and press with a compression force of 20 kN.

1. Mix all components.

2. Compress into 324mg tablets with 9mm bisect convex tooling.

1. Premix the CBD granule with Sodium Bicarbonate and Sodium Benzoate. Mix the color with Sodium Carbonate. Place Citric Acid in a bowl of a suitable blender.

2. Slowly add 2 mg of water to the Citric Acid and mix thoroughly to form a moist blend. Add to the blend, in sequence, while mixing, the Sodium Bicarbonate mix and the Sodium Carbonate color mix. Mix until uniformly distributed.

3. Compress tablets using suitably sized tooling. Cure the tablets, cool, and package in aluminum foil.

1. Pre-mix CBDC-75 with one-third quantity of the microcrystalline cellulose and one-half the quantity of the anhydrous lactose in a blender for 5 minutes at 20 rpm.

2. To the premix is added the remaining two-thirds of the microcrystalline cellulose and the remaining one-half of the anhydrous lactose. Blend for 10 minutes at 20 rpm.

3. Add croscarmellose sodium to the blended powders in step 2 and mix for 5 minutes at 20 rpm.

4. Add item 4 to the mixture after passing it through a 90-mesh screen and blend for an additional 5 minutes at 20 rpm.

5. Compress into 400 mg tablets, using a suitable punch.

A mixture containing CBDC-75, mannitol, maize starch, and microcrystalline cellulose is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 130 mg in the mas

1.Gum base powder and active ingredient (Caffeine salicylate) are mixed well in mortar.

2. Soy lecithin, sorbitol, mannitol, sweetner, and L-menthol are added to gum base and active mix

3.After thorough mixing, add lubricant and glidant.

1. Screen items 1, 7, and 8 separately through a 40-mesh sieve.

2. Blend items 1 to 6 and 9 in a V-shaped blender, and mix for 3 minutes.

3. Add item 8 to the blender and mix for another 5 minutes.

4. Compress, using 7 kg pressure and 3/8-in., flat, bevelededge punches to produce tablets with an average weight of 311 mg.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 305mg tablets with 8mm bisect convex tooling.

Note: If flowability for mixture is not high enough, about 1% silicon dioxide could be added.

1. Pass sorbitol and xylitol through 18 mesh sieve.

2. Mix sieved components in mixer for five minutes at 46rpm (rotations per minute).

3. Add magnesium stearate and mix for additional two minutes.

4. Compress into 150mg tablets with 7mm flat face tooling.

Note: Tablets compressed in environment with 40% relative humidity.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 502mg tablets with 12mm bisect tooling.

1. Dry saccharin sodium and tartaric acid for 1 hour at 100�C.

2. Mix all components.

3. Pass through a 20 mesh sieve.

4. Compress into 42mg tablets with 5mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 51mg tablets with 5mm bisect tooling.

1. Pass items 1 to 4 through a 250 mesh screen and blend for 10 minutes.

2. Add item 5, blend for 1 minute, and pass the mixture through a #11 sieve.

3. Compression at low compression force.

1. Blend Dry plant extract and excipients, except magnesium stearate, for 12 minutes by tumbling.

2. Add corresponding amount of magnesium stearate and blended for another 4minutes.

3. Compress for 5 seconds.

1. Mix ingredient sodium flouride and one-third of EMDEX® for 10 minutes.

2. Add remaining amount of EMDEX® and color and mix thoroughly for 20 minutes.

3. Add grape flvor and blend for 10 minutes.

4. Add magnesium stearate, blend 5 additional minutes, and compress.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 465mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 470mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 496mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 510mg tablets with12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 509mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 413mg tablets with 10mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 618mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 426mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 35 mesh sieve.

3. Compress into 419mg tablets with 12mm bisect tooling.

1. Mix nystatin and lactose monohydrate.

2. Granulate nystatin mixture with isopropanol.

3. Dry granulated mixture then pass through a 20 mesh sieve.

4. Mix crospovidone and magnesium stearate.

5. Add crospovidone mixture to granulated mixture.

6. Compress into 270mg tablets with 9mm bisect convex tooling.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 401mg tablets with 12mm bisect tooling.

1. Mix phenolphthalein and dicalcium phosphate.

2. Mix povidone and isopropanol or ethanol.

3. Granulate phenolphthalein mixture with povidone solution.

4. Mix crospovidone and magnesium stearate.

5. Pass mixture through a 20 mesh sieve.

6. Compress into 385mg tablets with 9mm bisect convex tooling.

Tocopheryl acetate dry powder 50%, spray-dried with gelatin

1. Mix all components.

2. Pass through a 35 mesh sieve.

3. Compress into 66mg tablets with 6mm bisect tooling.

1. Mix all components, and press with a low-compression force.

2. Compress into 518-mg tablets, using 12-mm biplanar punches.

1. Mix all components.

2. Compress into 518mg tablets with 12mm bisect tooling.

1. Mix all components and pass through a 0.5-mm sieve.

2. Press to tablets at 66 mg.

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

1. Blend half of the Starch 1500 with the fumed silica and CBD Granulate for 5 minutes.

2. Pass this mixture through a 40-mesh screen and return to blender.

3. Add the remaining starch 1500 to the material in step 1 and blend for 5 additional minutes.

4. Add the microcrystalline cellulose (MCC 102) and stearic acid to the material from step 2 and blend for an additional 10 minutes.

5. Add the magnesium stearate to the material from step 3 and blend for an additional 5 minutes.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 212mg tablets with 8mm bisect tooling.

1. Mix all components, pass through an 0.8-mm sieve.

2. Compress into lozenge, using 8-mm biplanar punches.

1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.

2. Mix and compress at low forces.

1. Mix naproxen and 6g povidone.

2. Mix 4g povidone, PEG-40 hydrogenated castor oil, and water.

3. Granulate naproxen mixture with povidone-castor oil solution.

4. Dry granulated mixture then pass through a 20 mesh screen.

5. Add lactose powder, stearic acid, croscarmellose sodium, magnesium stearate, and PEG 6000 powder.

6. Compress into 441mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 620mg tablets with 11mm standard convex bisect tooling.

1. Mix alpha-methyldopa with dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate alpha-methyldopa mixture with povidone solution.

4. Pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with the dry granulated mixture.

7. Compress into 362mg tablets with 11mm biscect tooling.

1. Mix aluminum acetylsalicylate, mannitol, and corn starch.

2. Mix povidone, Lutrol® E 6000, and isopropanol.

3. Granulate aluminum acetylsalicylate with povidone solution.

4. Dry the granulated mixture then pass through a 20 mesh sieve.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 540mg tablets with 12mm bisect tooling.

1. Mix Amoxicillin Trihydrate, Health in Gum® PWD-01, and Menthol in porcelain mortar.

2.Pass through 100# sieve

3.Mix blend with AEROSIL® fumed silica, Talc, and Aspartame for 5 minutes.

4.Keep in freeze for 30 minutes.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

4. Compress into 500mg tablets with 12mm bisect tooling.

1. Blend all the ingredients, except stearic acid for 25 minutes.

2. Screen in stearic acid and blend for an additional 5 minutes.

Note: It is important to use free-flowing types of ascorbic acid due to the high concentration in the formulation. Ascorbic acid concentration could be increased slightly by using more MCC and less Starch 1500. Stearic acid, Sterotex®, Compritol 888®, and Lubritab® are interchangeable in most formulations.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 477mg tablets with 12mm bisect tooling.

Note: If the bran is not milled, the hardness of tablet is higher but the content uniformity is less.

1. Mix milled bran wheat and dicalsium phosphate.

2. Mix povidone with water.

2. Wet granulate milled bran wheat mix with povidone solution.

3. Pass mixture through a 20 mesh sieve.

4. Mix polyethylene glycol 6000 powder with magnesium stearate.

5. Mix polyethylene glycol 6000 mix with granulated mixture.

6. Compress into 467mg tablets with 12mm bisect tooling.

1. Mix calcium lactate, calcium gluconate, calcium carbonate, sodium bicarbonate, tartic acid, and 48g povidone.

2. Mix 12g povidone with Isopropanol.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, polyethylene glycol 6000 powder, and flavour.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 2500mg tablets with 22mm bisect tooling.

1. Granulate mixture of items 1 to 4 with item 5, and pass through a 1-mm sieve.

2. Dry until a relative powder humidity of 90% is reached.

3. Add solution of items 6 and 7, and pass again through a 0.8-mm sieve.

4. Dry the granules, and press into 481-mg tablets using lowcompression force and 12-mm planar punches

5. Dry the obtained tablets.

1. Mix chloroquine diphosphate and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate chloroquine diphosphate mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, silicon dioxide, and talc.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 361mg tablets with 9mm bisect tooling.

1. Mix mefenamic acid and cornstarch.

2. Mix povidone and isopropanol.

3. Granulate mefenamic acid mixture with povidone solution.

4. Sieve granulted mixture and dry.

5. Mix crospovidone, microcrystalline cellulose, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 404mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 600mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 495mg tablets with 12mm bisect tooling.

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components.

3. Compress into 761mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 495mg tablets with 12mm bisect tooling.

1. Mix sulfathiazole, dicalcium phosphate, and povidone.

2. Granulate sulfathiazole mixture with water

3. Pass through 20 mesh sieve then dry.

4. Mix crospovidone and magnesium stearate.

5. Add crospovidone mixture to granulated mixture.

6. Compress into 512mg tablets with 12mm bisect tooling.

7. Note: Dicalcium phosphate can be replaced with lactose monohydrate for longer disintegration rate.

1. Mix tetracycline hydrochloride, lactose monohydrate, povidone, and crospovidone.

2. Pass mixture through 35 mesh sieve.

3. Mix talc, silicon dioxide, and calcium arachinate.

4. Add talc mixture to sieved mixture.

5. Compress into 505mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 157mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 120mg tablets with 8mm bisect tooling.

1. Mix aspartame, dicalcium phosphate, and copovidone.

2. Wet granulate aspartame mixure with water.

3. Pass mixture through a 20 mesh sieve

4. Mix crospovidone and Polyethylene glycol 6000 powder.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 60mg tablets with 5mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 122mg tablets with 8mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix intensively.

3. Compress 150mg tablets with 8mm bisect tooling.

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components.

3. Compress into 82mg tablets with 6mm bisect tooling.

1. Screen pyrilamine maleate, stearic acid, and magnesium stearate through 40 mesh sieve.

2. Blend pyrilamine maleate and lactose for 3 minutes in V blender.

3. Add microcrystalline cellilose, AcDiSol, and CAB-O-SIL® to step 2 and blend for 17 minutes.

4. Add stearic acid to step 3 and blend for 3 minutes.

5. Add magnesium stearate to step 4 and blend for 5 minutes.

1. Mix all components.

2. Pass through sieve.

3. Compress into 197mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 499mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh mm sieve.

3. Compress into 100mg tablets with 8mm bisect tooling.

1. Mix cimetidine and corn starch.

2. Mix povidone and water.

3. Granulate cimetidine mixture with povidone solution, then pass through a 20 mesh screen.

4. Add magnesium stearate.

5. Compress into 427mg tablets with 12mm bisect tooling.

Mix all components, pass through a 0.5-mm sieve, and press with low compression force.

1. Mix paracetamol, norephedrine hydrochloride, phenyltoloxamine, and corn starch.

2. Mix povidone and ethanol.

3. Granulate paracetamol mixture with povidone solution.

4. Dry granulated mixture then pass through a 20 mesh screen.

5. Mix crospovidone and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 601mg tablets with 12mm bisect tooling.

1. Mix citric acid with low caffeine instant coffee and calcium.

2. Mix sodium bicarbonate with maltodextrin and natural coffee essences.

3. Before compression, mix materials in room temperature of 20? and 20% of relative humidity in order to ensure that environment does not affect water content in the materials.

Note: Drying process was conducted at 50? to minimize water content in the material and was conducted before mixing.

1. Blend allopurinol and Firmaoil for 10 minutes.

2. Add sodium starch glycolate and blend for 10 more minutes.

3. Add talc and CAB-O-SIL® and blend for 3- 5 minutes.

4. Add magnesium stearate and blend 5 more minutes.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 615mg tablets with 11mm bisect convex tooling.

1. Mix paracetamol, sucrose, crospovidone, orange flavour, and strawberry flavour.

2. Mix povidone and ethanol.

3. Granulate paracetamol mixture with povidone solution, then sieve.

4. Compress into 1620mg tablets with 20mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 600mg tablets with 12mm bisect convex tooling.

Mix all items for 15 minutes, pass through a sieve, add Magnesium Stearate and mix for an additional 1 minute. Press with medium compression force.

1. Pass all components through an 0.8-mm sieve, mix, and press with low-compression force.

2. Compress using 12-mm biplanar punches.

3. Crospovidone may be omitted and the tablet weight adjusted.

1. Discharge all the ingredients through a 0.5-mm sieve, and mix for 10 minutes.

2. Press into 132-mg CBD tablets using medium-compression force and 8-mm biplanar punches.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 355mg tablets with 8mm bisect convex tooling.

1. Mix acetaminophen, Solka Floc-BW 100, and Emcocel together for 10 minutes.

2. Add CAB-O-SIL® and Explotab®, blend for 10 minutes.

3. Add magnesium stearate, and blend for 5 minutes. and compress at maximum compression force.

Note: Harder tablets can be made by replacing additional portions of Solka Floc with Emcocel.

1. Mix calcium gluconate and lactose monhydrate.

2. Mix 11g povidone with isopropanol.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 500mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 601mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 458mg tablets with 12mm bisect tooling.

Direct Compression

1. Mix sulfamethoxazole and trimethoprim.

2. Mix povidone and isopropanol.

3. Granulate sulfamethoxazole mixture with povidone solution.

4. Pass through 20 mesh sieve then dry.

5. Mix crospovidone, talc, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 546mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 800mg tablets with 12mm bisect tooling.

1. Weigh all excipients and pass through 20 mesh sieve individually.

2. Mix ground cinnamon, lactose, and sodium sachrine with geometric mixing method for 15 minutes.

3. Add talc and magnesium stearate; mix thoroughly.

Note: Mannitol can be used in place of lactose in the same amount.

1. Weigh all excipients and pass through 20 mesh sieve individually.

2. Mix ground clove, lactose, and sodium sachrine with geometric mixing method for 15 minutes.

3. Add talc and magnesium stearate; mix thoroughly.

Note: Mannitol can be used in place of lactose in the same amount.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 620mg tablets with 12mm bisect tooling.

1. Mix ethambutol and dicalcium phosphate.

2. Mix povidone and isopropanol.

3. Granulate ethambutol mixture with povidone solution, Dry the mixture then pass through a 20 mesh sieve.

4. Mix crospovidone and magnesium stearate.

5. Mix crospovidone mixture with dry granulated mixture.

6. Compress into 1112mg tablets with 20mm oblong tooling.

1. Mix ibuprofen with silicon dioxide.

2. Add remaining components.

3. Compress into 533mg tablets with 12mm bisect tooling.

1. Mix povidone with water.

2. Granulate mannitol with povidone solution, then pass through a 20 mesh screen.

3. Mix ibuprofen, crospovidone, silicon dioxide, and magnesium stearate.

4. Addibuprofen mixture to granulated mixture.

5. Compress into 774mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 645mg tablets with 12mm bisect convex tooling.

CBDC-75 is first blended with one-third of microcrystalline cellulose 102 and with one-half of anhydrous lactose. The premixture obtained is then blended with both remaining excipients and it is mixed again. Sodium salt of carmellose is added under mixing to be followed with magnesium stearate to finish the mixture blending. When homogenized by forth mixing the mixture is subjected to the compression.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 149mg tablets with 8mm bisect tooling.

1. Screen CAB-O-SIL® through a 2O mesh sieve.

2. Screen stearic acid and magnesium stearate through a 40 mesh sieve.

3. Blend furosemide, microcrystalline cellulose, and lactose in V blender without intensifier bar for 1 minute and then blend with aid of intensifier bar for 30 seconds and without intensifier bar for 1.5 minutes.

4. Add croscarmellose and hydrophobic fumed silica, blend for 3 minutes.

5. Add stearic acid and blend for 3 minutes.

6. Add magnesium stearate and blend for 5 minutes.

7. Discharge blender and pass blend through 40 mesh sieve using oscillating granulator.

8. Charge blender with sieved blend and blend for 5 minutes.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 205mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 150mg tablets with 8mm bisect convex tooling.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components, then compress into 231mg tablets with 9mm bisect convex tooling.

1. Mix copovidone, Lutrol, and isopropanol .

2. Granulate horsetail extract powder with copovidone solution..

3. Dry then pass through a 20 mesh screen.

4. Mix crospovidone with magnesium stearate.

5. Mix crospovidone mix with granulated mix.

6. Compress into 489mg tablets with 12mm bisect tooling.

1. Mix naproxen and crospovidone.

2. Mix povidone and water.

3. Granulate naproxen mixture with povidone solution then pass through 20 mesh screen.

4. Add magnesium stearate.

5. Compress into 496mg tablets with 12mm bisect tooling.

1. Mix rifampicin and corn starch.

2. Mix povidone and ethanol.

3. Granulate rifampicin mixture with povidone solution.

4. Dry granulated mixture then sieve.

5. Mix crospovidone, stearic acid, magnesium stearate, and silicon dioxide.

6. Mix granulated mixture with crospovidone mixture.

7. Compress into 550mg tablets with 12mm bisect tooling.

1. Mix sulfadiazin and lactose monohydrate.

2. Mix povidone and water.

3. Granulate sulfadiazin mixture with povidone solution.

4. Dry granulated mixture then pass through 20 mesh sieve.

5. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 602mg tablets with 12mm bisect tooling.

1. Add CBDC-75, gelatin, and croscarmellose sodium, one item at a time, in a suitable blender, and mix for 15 minutes.

2. Add talc and magnesium stearate, and mix for an additional 5 minutes.

3. Compress into 230-mg tablets, using 6-mm punches.

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 202mg tablets with 8mm bisect tooling.

Note: If the content uniformity does not meet the requirements it would be recommended to prepare a premix of the active ingredient with a small part of the Ludipress� or with lactose monohydrate before mixing with the other components of the formulation.

Pass Mannitol, Sodium Starch Glycolate, and Croscarmellose Sodium were through a 100 mesh screen prior to mixing.

Mix Ondansetron Hydrochloride to sieved blend of powder.

Add and mix mint Flavor, Aerosil®, and Magnesium Stearate

1. Mix all components.

2. Pass through sieve.

3. Compress into 206mg tablets with 8mm bisect tooling.

Note: If blend is not uniform, a premix of triamcinolone and Ludipress� or lactose monohydrate should be prepared separately before mixing with other excipients.

1. Pass all components through a 20 mesh sleeve.

2. Intensively mix sieved components.

3. Compress into 97.6mg tablets with 6mm tooling.

Note: If blend is not uniform, a premix of terazosin chloride and Ludipress� or lactose monohydrate should be prepared separately before mixing with other excipients.

1. Pass magnesium stearate trough a 70 mesh sieve.

2. Pass remaining components through 35 mesh sieve.

3. Blend sieved magnsium stearate with remaining sieved components.

4. Compress into 750mg tablets with 12mm bisect tooling.

Note: Capping likelihood is increased with convex tooling.

1. Mix alpha-methyldopa and lactose monohydrate.

2. Mix povidone and isopropanol.

3. Granulate alpha-methyldopa mixtures with povidone solution, then pass through a 20 mesh sieve.

4. Mix crospovidone, silicon dioxide, and magnesium stearate.

5. Mix crospovidone mixture with granulated mixture.

6. Compress into 540mg tablets with 12mm bisect tooling.

Note: Oblong tooling is recommended for tablet cores that are to be coated.

1. Mix ampicillin trihydrate and sorbitol.

2. Mix copovidone with isopropanol or water.

3. Wet granulate ampicillin mixture with copovidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone, magnesium stearate, and silicon dioxide.

6. Mix crospovidone mixture with granulated mixture.

7. Compress 822mg tablets with 16mm bisect tooling.

1. Mix ashwagandha powder, excipients, crospovidone, and camphor in a plastic container.

2. After compressing the tablets, vacuum driy at 60? until a constant weight was obtained.

1. Mix calcium glycerophosphate and corn starch.

2. Mix povidone with water.

3. Granulate calcium mixture with povidone solution.

4. Dry the granulated mixture and pass through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix crospovidone mixture with granulated mixture.

7. Compress into 650mg tablets with 12mm bisect tooling.

1. Mix griseofulvin and copovidone.

2. Dissolve griseofulvin mixture in dimethyl formamide.

3. Evaporate to dryness and pass through a 35 mesh screen.

4. Mix crospovidone, lactose monohydrate, magnesium stearate, and silicon dioxide.

5. Mix crospovidone mix with granulated mix.

6. Compress into 751mg tablets with 12mm bisect tooling.

1. Mix magaldrate, lactose monohydrate, and orange flavour.

2. Mix povidone, banana flavour, cocos flavour, saccharin sodium, and water.

3. Granulate magaldrate mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen then dry.

5. Mix silicon dioxide and magnesium stearate.

6. Add silicon dioxide mixture to granulated mixture.

7. Compress into 1000mg tablets with 16mm bisect tooling.

1. Mix all components.

2. Pass through a 35 mesh sieve.

3. Compress into 499mg tablets with 12mm bisect tooling.

1. Mix metformin hydrochloride, dicalcium phosphate, and 15g povidone.

2. Mix 8g copovidone and 90g isopropanol.

3. Granulate metformin hydrochloride mixture with copovidone solution.

4. Mix crospovidone with PEG 6000 powder.

5. Mix crospovidone mixture into granulated mixture, then pass through a 20 mesh sieve.

6. Compress into 650mg tablets with 12mm bisect tooling.

Note: Reduce the amount of povidone if tablets are too hard.

1. Mix metronidazole and sorbitol.

2. Mix povidone and ethanol.

3. Granulate metronidazole mixture with povidone solution.

4. Pass through 20 mesh sieve and dry.

5. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

6. Mix crospovidone mixture into granulated mixture.

7. Compress into 755mg tablets with 16mm bisect tooling.

1. Mix all ingredients except magnesium stearate thoroughly using double cone blender for 15 minutes. Set the speed of the blender to 35 revolutions per minute.

2. Compress mixed excipients into a 10mm slug or tablets using a rotary tableting press.

3. Crush slug into small granules using an oscillating granulator. The granules produced will be used for final compression.

4. Add magnesium stearate to the formulation granules and mix again using double cone blender at 35 revolutions per minute for 15 minutes.

1. Mix povidone and water.

2. Granulate nalidixic acid with povidone solution.

3. Dry granulated mixture then pass through a 20 mesh screen.

4. Mix crospovidone and magnesium stearate.

5. Add crospovidone mixture to granulated mixture.

6. Mix for 10 minutes.

7. Pass through 20 mesh screen again.

8. Compress into 545mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 683mg tablets with 12mm bisect tooling.

Note: If flowability for mixture is not high enough, silicon dioxide should be added.

1. Mix paracetamol, sodium bicarbonate, tartaric acid, and dextrose.

2. Mix povidone and isopropanol.

3. Granulate paracetamol mixture with povidone solution.

4. Pass the granulated mixture through a 20 mesh screen.

5. Add polyethylene glycol 6000 powder.

6. Compress into 1700mg tablets with 16mm bisect tooling.

1. Pass magnesium stearate through a 70 mesh screen.

2. Mix all other components on the side.

3. Pass mixed components through a 20 mesh screen.

4. Add sieved magnesium stearate to mixed components.

5. Compress into 703mg tablets with 12mm bisect tooling.

1. Mix paracetamol, dicalcium phosphate, 12g crospovidone, and copovidone.

2. Mix povidone and ethanol.

3. Mix 12g crospovidone and polyethylene glycol set aside .

4. Granulate paracetamol mixture with povidone solution

5. Dry granulated mixture then sieve and mix with dry crospovidone mixture.

6. Compress into 587mg tablets with 11mm bisect convex tooling.

1. Mix probenecid and corn starch.

2. Mix povidone and ethanol.

3. Granulate probenecid mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh sieve.

5. Mix crospovidone, silicon dioxide, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 674mg tablets with 12mm bisect convex tooling.

1. Mix all components.

2. Pass through a sieve.

3. Compress into 652mg tablets with 12mm bisect tooling.

1. Mix pyrazinamide and corn starch.

2. Mix povidone and ethanol.

3. Granulate pyrazinamide mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix granulated mixture with crospovidone mixture.

7. Compress into 605mg tablets with 12mm bisect tooling.

1. Mix sucralfate, sodium alginate, and corn starch.

2. Mix povidone and ethanol.

3. Granulate sucralfate mixture with povidone solution.

4. Pass granulated mixture through a sieve.

5. Mix crospovidone and magnesium stearate.

6. Mix granulated mixture with crospovidone mixture.

7. Compress into 660mg tablets with 12mm bisect tooling.

1. Mix sulfadimidine and lactose monohydrate.

2. Mix povidone and water.

3. Granulate sulfadiazin mixture with povidone solution.

4. Dry granulated mixture then pass through 20 mesh sieve.

5. Mix crospovidone, talc, silicon dioxide, and calcium arachinate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 610mg tablets with 12mm bisect tooling.

1. Mix valproate sodium and corn starch.

2. Mix povidone and isopropanol.

3. Granulate valproate sodium mixture with povidone solution then sieve.

4. Mix crospovidone and magnesium stearate.

5. Mix dry granulated mixture with crospovidone mixture.

6. Compress into 607mg tablets with 12mm bisect tooling.

In a mixer, pour and mix for 5 minutes in 6 steps:

1. Tartaric acid and sodium bicarbonate

2. Ascorbic acid and sodium ascorbate

3. Sorbitol DC, flavor and sodium saccharinate

4. A third of PEG 6000 and sodium benzoate

5. A third of PEG 6000 and sodium benzoate

6. A third of PEG 6000 and sodium benzoate. The powder is ready to be compressed.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 175mg tablets with 8mm bisect tooling.

1. Pass CBDC-75 granulate, sodium ascorbate, sorbitol, lactose, FD&C Yellow Dye, microcrystalline cellulose, silica gel, flavors, and sodium cyclamate through a 420-mircrogram screen.

2. Using a comminuting mill, pass the coarse granules through a 420-microgm screen (knives forward, medium speed).

3. Transfer milled materials to a suitable blender, and blend for 5 minutes.

4. Screen the magnesium stearate by hand through an 840-microgm screen, and transfer to blender.

5. Mix for 1 minute.

6. Compress using 18-mm standard concave punches.

Pass all ingredients through a 0.8-mm sieve and press with high-compression force.

1. Mix all ingredients except Magnesium Stearate for 10 minutes.

2. Add Magnesium Stearate and mix for 1 minute.

3.  Compress using low compression forces.

A mixture containing CBDC-75, Lactose, and Prosolv 50 is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 355mg tablets

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 154mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 226mg tablets with 8mm bisect tooling.

1. Mix diclofenac sodium, dicalcium phosphate, and povidone.

2. Granulate diclofenac sodium mixture with ethanol, then pass through a 20 mesh screen.

3. Mix crospovidone and magnesium stearate.

4. Add crospovidone mixture to dry granulated mixture.

5. Compress into 209mg tablets with 8mm bisect convex tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 215mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

4. Compress into 300mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 328mg tablets with 8mm bisect tooling.

1. Mix hydrochlorothiazide, lactose monohydrate, and copovidone.

2. Granulate hydrochlorothiazide mixture with propanol, then pass through a 20 mesh screen.

3. Mix crospovidone and magnesium stearate.

4. Add crospovidone mixture to granulated mixture.

5. Compress into 495mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 303mg tablets with 8mm bisect tooling.

1. Mix indomethacin and lactose monohydrate.

2. Mix povidone and water.

3. Granulate indomethacin mixture with povidone solution.

4. Pass granulated mixture through a 20 mesh screen.

5. Mix crospovidone, silicon dioxide, and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 372mg tablets with 12mm bisect convex tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 230mg tablets with 8mm bisect convex tooling.

1. Mix all components.

2. Pass through a sieve.

3. Compress into 496mg tablets with 12mm bisect tooling.

1. Pass all components through a 35 mesh sleeve.

2. Mix sieved components, then compress into 208mg tablets with 8mm tooling.

1. Mix glutaminic acid and sorbitol.

2. Mix povidone and water.

3. Granulate glutaminic acid mixture with povidone solution.

4. Dry then pass through a 20 mesh screen.

5. Mix crospovidone and magnesium stearate.

6. Add crospovidone mixture to granulated mixture.

7. Compress into 719mg tablets with 12mm bisect tooling.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 115mg tablets with 6mm bisect tooling.

Mix all components, pass through an 0.8-mm sieve, and press with medium-compression force.

1. Pass item 2 through 0.7-mm sieve and collect in a stainless steel container.

2. Charge half quantity of step 1 in a tumbler.

3. Pass items 1 and items 3 to 5 through 0.5-mm sieve and collect in a container.

4. Add 15% Mannitol from step 1 to step 3 and mix well.

5. Compress at medium force.

1. Pass all components through an 0.8-mm sieve, mix, and press with very low-compression force (4 kN).

2. Compress into 202-mg tablets, using 8-mm biplanar punches.

3. This is a very low active ingredient formulation (5 mg), if content uniformity is a problem, prepare a premix of the active ingredient with a small part of the lactose monohydrate before mixing with the other components of the formulation.

1. Mix all components.

2. Pass through a 20 mesh mm sieve.

3. Compress into 175mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 213mg tablets with 8mm bisect tooling.

Note: If the content uniformity does not meet the requirements it would be recommended to prepare a premix of the active ingredient with a small part of Ludipress� or with lactose monohydrate before mixing with the other components of the formulation.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 201mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 176mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 109mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 99mg tablets with 6mm bisect tooling.

1. Mix all components.

2. Pass through sieve.

3. Compress into 206mg tablets with 8mm bisect tooling.

Note: If blend is not uniform, a premix of triamcinolone and Ludipress� or lactose monohydrate should be prepared separately before mixing with other excipients.

Active ingredient and all additives are homogeneously blended using geometric dilution after passing through 500 micron screen sieve.

PEG 3350 is added to the mixture.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 301mg tablets with 8mm bisect tooling.

1. Mix copovidone and ethanol or isopropanol.

2. Granulate sodium chloride with copovidone mixture.

3. Pass through 20 mesh sieve then dry.

4. Mix caroate, tartic acid, sodium bicarbonate, and PEG 6000.

5. Mix caroate mixture with dry granulated mixture.

6. Compress into 2000mg tablets with 20mm bisect tooling.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 214mg tablets with 9mm bisect convex tooling.

1. Pass all components through a 20 mesh sleeve.

2. Mix sieved components.

3. Compress into 1200mg tablets with 16mm bisect tooling.

1. Pass all components through an 0.8-mm sieve and mix. Press with medium- or high-compression force at maximum 30% relative humidity.

3. Use 12-mm biplanar punches for 602-mg tablets.

1. Mix simethicone, sucrose, and 7g povidone.

2. Mix 3.5g povidone and isopropanol.

3. Granulate simethicone mixture with povidone solution.

4. Dry granulated mixture then pass through 20 mesh sieve.

5. Mix silicon dioxide and magnesium stearate.

6. Thoroughly mix granulated mixture with silicon dioxide mixture.

7. Compress into 442mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix sieved components.

3. Compress into 605mg tablets with 12mm bisect tooling.

1. Mix sorbitol and silicon dioxide.

2. Mix sorbitol mixture with simethicone oil and pass through 20 mesh sieve.

3. Mix Ludipress�, menthol powder, and magnesium stearate.

4. Add Ludipress� mixture to sieved mixture and mix thoroughly.

5. Pass final mixture through 20 mesh sieve.

6. Compress into 870mg tablets with 16mm bisect tooling.

1. Mix copovidone with ethanol or isopropanol.

2. Granulate copovidone solution with sodium chloride.

3. Pass mixture through 20 mesh sieve.

4. Dry the granulated mixture.

5. Mix caroate, crospovidone, and polyethylene glycol 6000 powder.

6. Mix caroate mixture with the granulated mixture.

7. Compress into 2000mg tablets with 20mm bisect tooling.

1. Pass all components through a 20 mesh sieve sieve.

2. Mix then compress into 204mg tablets with size 8mm bisect tooling.

1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.

2. Add Magnesium stearate and mix an additional 1 minute and compress.

1. Mix aminophylline, potato starch, corn starch, and 3g copovidone.

2. Mix 3g copovidone with water.

3. Granulate aminophylline mixture with copovidone solution then pass through a 20 mesh sieve.

4. Dry mixture.

5. Mix magnesium stearate, talc, and polyethylene glycol 6000.

6. Mix magnesium stearate mixture with granulated mixture, then pass through a 35 mesh sieve.

7. Compress into 179mg tablets with 8mm bisect tooling.

1. Mix all components.

2. Pass mixture through a 20 mesh sieve.

3. Compress into 436mg tablets with 12mm bisect tooling.

1. The CBDC-75 Granulate is coated with a layer of a taste-masking composition with a thickness of about 3 to 10 micrograms. The coating should be substantially free of cracks, holes, and other imperfections when examined under a scanning electron microscope at 100 to 500 magnification.

2. Charge items 1 to 7 in a suitable blender and mix for 20 minutes.

3. Add item 8 to step 2 and blend for 2 minutes.

4. Compress the appropriate quantity.

1. Granulate acetaminophen powder, caffeine powder, acetysalicylic acid powder, and copovidone in a roller compactor.

2. Pass granules through through a 20 mesh sieve with magnesium stearate, silicon dioxide, and crospovidone, then blend for 10 min in VH mixer.

3. Compress into tablets with a force of about 12 kN.

1. Mix all components.

2. Pass through a 20 mesh sieve.

3. Compress into 400mg tablets with 12mm bisect tooling.

1. Pass all components through a 20 mesh sieve.

2. Mix components.

3.Compress into 2000mg tablets with 20mm bisect tooling.

Prepared by direct compression using a single punch tablet press with 13mm biconvex tooling.

Average weight of each lozenge is about 850mg.